Improvement in renal function of Hyperhomocysteinemic rats by panax ginseng

Hyperhomocysteinemia is a condition characterized by elevated levels of homocysteine in the blood, which has been linked to various cardiovascular and renal complications, including impaired function. , widely used medicinal herb, shown possess antioxidant, anti-inflammatory, vasoprotective properties. However, its potential role improving function hyperhomocysteinemic conditions remains largely unexplored. metabolic disorder associated with This study aimed investigate therapeutic effects Panax Ginseng on rats. Male Wistar rats There were five animals per group. Group 1 functioned as control group, receiving typical meal (chow feed) unlimited water. L-methionine (1.7 g/kg/day, p.o.) was given group 2 (HHCY Control) once daily. A modest dosage ginseng (50 mg/kg body weight) administered orally third (test drug 1). The fourth 2) got same combination (high dosage, 100 weight). In addition, second, third, groups received intraperitoneal doxorubicin injections at 5 after hour administration intervals 15 days order produce Hyperhomocysteinemia-mediated nephrotoxicity. After 28 trial, slaughtered, blood homocysteine, creatinine, urea measured. We measured amounts urea, serum. effectively improved attenuated histopathological changes These findings suggest that may have renoprotective effect Hyperhomocysteinemia-induced dysfunction.